Respiratory mucous secretions in patients with cystic fibrosis: relationship between levels of highly sulfated mucin component and severity of the disease.

摘要: The tracheobronchial secretions from cystic fibrosis patients contained higher levels of protein, DNA and sialic acid than the healthy donors. In contrast, neutral hexose content in CF was strikingly lower normal subjects. were found to increase with increasing severity disease. alterations these chemical parameters increased disease are as a result mucin secretions, especially highly sulfated component. Since mucins considered, large extent, responsible for viscoelastic properties enhanced component severity, may contribute altered rheological hence decreased mucociliary transport secretions.