Chronic viral infections of the central nervous system: Aspects specific to multiple sclerosis.

摘要: The involvement of a viral infection in the physiopathology multiple sclerosis has been said to cause certain viruses target central nervous system and induce neuroinflammation leading cell dysfunction, as seen, for example, by demyelination or neuronal death. most recent results literature have focused on Herpes family (HHV-6 HHV-4/Epstein-Barr virus) their possible role development sclerosis. Even if no virus identified so far etiological agent, our aim here is show that some may be responsible triggering sustaining neurological diseases. This particularly case Paramyxoviruses, late appearance functional alterations, Picornaviruses, inducing breakdown immune tolerance, epitope spreading demyelination, T B lymphocyte activation, lymphocytes dysregulation autoimmunity after reactivation. Therefore, "common" can play potential modulators systems which, specific context dysimmunity genetic susceptibility, stimulate favorable background Tracing studying patients improve understanding actual physiopathology.