XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy.

摘要: // Chang-Jiang Qin 1,2 , Xin-Ming Song 1 Zhi-Hui Chen Xue-Qun Ren 2 Kai-Wu Xu Hong Jing 3 and Yu-Long He Department of Gastrointestinal Pancreatic Surgery, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, China Huaihe Hennan Kaifeng, Pathology, Correspondence to: Song, email: Keywords : XRCC2, rectal cancer, preoperative radiotherapy, radioresistance Received April 21, 2015 Accepted July 16, Published 22, Abstract XRCC2 has been shown to increase the some cancers. Here, expression was investigated as a predictor radiotherapy (PRT) treatment response in locally advanced cancer (LARC). found be overexpressed tissues resected from patients who underwent surgery without PRT. In addition, overall survival for LARC improved XRCC2-negative compared with XRCC2-positive after PRT ( P < 0.001). also associated an radioresistance. Conversely, -deficient cells were more sensitive irradiation vitro higher proportion these cell death induced by G2/M phase arrest apoptosis. When knocked down, repair DNA double-strand breaks caused impaired. Therefore, may increases repairing preventing Moreover, present data suggest that is useful predictive biomarker patients. Thus, inhibition or activity represents potential therapeutic strategy improving