In vitro effects of epidermal growth factor (EGF) on growth of urological malignant tumor cells

摘要: It is well known that Epidermal Growth Factor (EGF) a cell-regulating factor for variety of tissues in vitro including normal and malignant cells. Furthermore, Takano et al reported decreased expression EGF receptor clones human cancer KB cell line might be one the pleiotropic properties multidrug-resistant However, both influence on urological lines relation between receptors sensitivities antitumor drugs these have not been fully described. We studied effects growth 4 transitional carcinoma bladder (TCCaB), 1 squamous (SCCaB), 5 renal (RCC) 3 prostatic (CaP), as relationship number drug against methotrexate, vinblastine, adriamycin, cisplatin etoposide (VP16). The present results determined by colony forming efficiency method showed exogenous addition to cultures at 0.1 ng/ml stimulated SCCaB 169.0%, inhibited RCC 2.9%-79.0%, relative control. more 125I-EGF binding assay, higher inhibition VP16 lines. These suggested vitro, we found phenomena were correlated with neither nor affinities receptors.(ABSTRACT TRUNCATED AT 250 WORDS)