Controlled trial of cumulative behavioural effects of a common bread preservative.

摘要: Objective:  Many anecdotes and one scientific report describe cumulative behavioural effects of bread preservative on children. Methodology:  Twenty-seven children, whose behaviour improved significantly the Royal Prince Alfred Hospital diet, which excludes food additives, natural salicylates, amines glutamates, were challenged with calcium propionate (preservative code 282) or placebo through daily in a double-blind placebo-controlled crossover trial. Results:  Due to four responders, there was no significant difference by anova weighted challenge Rowe Behaviour Rating Inventory means, but statistically existed proportion children behaviours ‘worsened’ (52%), compared ‘improved’ (19%), relative (95% confidence intervals 14−60%). Conclusions:  Irritability, restlessness, inattention sleep disturbance some may be caused healthy foods consumed daily. Minimizing concentrations added processed would reduce adverse reactions. Testing for toxicity should included additive safety evaluation.