Microsatellite Analysis of Posttransplant Lymphoproliferative Disorders: Determination of Donor/Recipient Origin and Identification of Putative Lymphomagenic Mechanism

摘要: The genetic mechanisms that give rise to posttransplant lymphoproliferative disorders (PTLDs) are not well established, yet previous studies have focused or) the role of immunosuppression and EBV infection. We investigated whether microsatellite analysis could: (a) determine recipient/donor origin tumor; (b) document novel alterations in PTLDs, i.e., instability. characterized seven cases PTLD (five B-cell two T-cell non-Hodgkin's lymphomas) which donor allograft tissue, normal recipient tissue from PTLDs were available. In each case, six loci analyzed. Five host (three lymphomas). lymphomas. Multiple showed instability host-derived lymphomas (28% PTLDs). These findings show may be used or suggest for first time defective DNA mismatch repair an underlying mechanism lymphomagenesis some PTLD.