Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy

摘要: Angiogenesis and co-optive vascular remodeling are prerequisites of solid tumor growth. Vascular heterogeneity, notably perivascular composition, may play a critical role in determining the rate cancer progression. The contribution pericyte heterogeneity to progression therapy response is unknown. Here, we show that angiopoietin-2 (Ang2) orchestrates breast with an effect on metastatic disease chemotherapy. Using multispectral imaging human specimens, report as defined by ratio PDGFRβ- desmin+ pericytes, provides information about epirubicin but not paclitaxel. 17 distinct patient-derived xenografts, demonstrate cell-derived influence stromal Ang2 production cell-defined control over vasculature heterogeneity. aggressive features tumors their therapies thus emerge engagement heterogeneous angiogenic programs.