Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis.

摘要: Although phospholipase C (PLC) is a crucial enzyme required for effective signal transduction and leukocyte activation, the role of PLC in polymicrobial sepsis remains unclear. In this study, we show that direct activator m -3M3FBS treatment significantly attenuates vital organ inflammation, widespread immune cell apoptosis, mortality mouse model induced by lethal cecal ligation puncture challenge. Mechanistically, -3M3FBS–dependent protection was largely abolished pretreatment mice with PLC-selective inhibitor U-73122, thus confirming agonism vivo. activation enhanced bactericidal activity hydrogen peroxide production neutrophils, it also IFN-γ IL-12 while inhibiting proseptic TNF-α IL-1β mice. second sepsis, inhibited following systemic LPS conclusion, agonizing central transducing can reverse progression toxic shock triggering multiple protective downstream signaling pathways to maintain function, survival, enhance microbial killing.