A simple attention test in the acute phase of a major depressive episode is predictive of later functional remission

摘要: Background Functional recovery after a major depressive episode (MDE) requires both clinical remission and preservation of cognitive skills. As attentional deficit may persist remission, leading to functional impairment, its role as prognosis marker needs be considered. Methods Five hundred eight depressed outpatients (DSM-IV) were assessed at baseline for symptoms (QIDS-SR), social functioning (Sheehan Disability Scale, SDS) attention through the d2 test trail making test, simple tests, respectively, requiring quote or interconnect relevant items. All patients treated by agomelatine, examined 6 8 weeks assess (QIDS-SR ≤ 5) and/or (SDS 6). Results At follow up, 154 (31%) in remission. Shorter cumulative duration prior depression, shorter present MDE, two parameters predictive such positive outcome, number omission mistakes (F1) being only one still significantly (P < .05) with multivariate approach. F1 was unchanged less than 11 had 2.27 times increased chance reach full dose–response relationship observed, regular increase outcome mistakes. Conclusions The stable marker, of, dose-effect for, plus It constitute specific deficit, involved resilience process that enables individuals develop more adequate strategies cope everyday activities.