Determinants of Blood Brain-Derived Neurotrophic Factor Blood Levels in Patients with Alcohol Use Disorder.
作者： Philippe Nubukpo , Nicolas Ramoz , Murielle Girard , Dominique Malauzat , Philip Gorwood
DOI: 10.1111/ACER.13414
关键词: Beck Depression Inventory 、 Population 、 Alcohol detoxification 、 Alcohol dependence 、 Mood disorders 、 Oncology 、 Suicidal ideation 、 Internal medicine 、 Psychology 、 Psychiatry 、 Brain-derived neurotrophic factor 、 Alcohol use disorder
摘要: SummaryBackground Blood Brain Derived Neurotrophic Factor (BDNF) levels are influenced by both addiction and mood disorders, as well somatic conditions, gender, genetic polymorphisms, leading to widely varying results. Depressive symptoms episodes frequently observed in patients with alcohol-use disorder, vary over time, making it a challenge determine which aspects specifically involved variations of serum BDNF this population. Methods We assessed 227 alcohol dependence detoxification program, at baseline after follow-up six months, for the AUDIT score, length dependence, number past programs. The Beck Depression Inventory information on current tobacco use, suicidal ideation, BMI, age, psychotropic treatments were also collected. Serum (ELISA) two polymorphisms gene (Val33Met rs962369) analyzed. Results The presence Met allele, markers history (γGT programs), depressive episode (but not score) significantly associated blood months. After controlling levels, allele an ongoing only variables changes BNDF months. Conclusions Low characteristics related consumption variants disorder patients. factors most strongly following treatment program depression. This article is protected copyright. All rights reserved.
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