Dynamic Diffusion Tensor Imaging Reveals Structural Changes in the Bilateral Pyramidal Tracts after Brain Stem Hemorrhage in Rats.

摘要: Background and Purpose: Few studies have concentrated on pyramidal tract (PY) changes after brain stem hemorrhage (BSH). In this study, we used a diffusion tensor imaging (DTI) technique histologic identification to investigate longitudinal PY both the contralateral ipsilateral sides experimental BSH. Methods: BSH was induced in 61 Sprague-Dawley rats by infusing 30 μl of autogenous tail blood into each rat’s right pons. DTI motor function examinations were performed repeatedly days 1, 3, 7, 14, 28 surgery. Fractional anisotropy, mean diffusivity, axial radial diffusivity measured bilateral PYs. The axon myelin injury evaluated study. Results: As compared with normal controls, PYs showed an early decrease late increase fractional anisotropy diffusivity. A progressive dramatic loss from day 1 found bilaterally. Early repair also detected pathologically Thus, deficits began improve 14 had almost completely disappeared 28. Conclusions: revealed dynamic BSH, which confirmed findings correlated alteration. These support idea that quantitative can track structural may serve as noninvasive tool predict prognoses patients