Aggressive behavior and anaplasia in pleomorphic xanthoastrocytoma: a plea for a revision of the current WHO classification

摘要: SUMMARY: Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic neoplasm that commonly affects children and young adults, presents with seizures. PXA typically supratentorial predilection to the temporal lobe, often involves cortex meninges. PXAs have favorable prognosis 10-year survival probability of >70%, are WHO grade II neoplasms. Recent observations studies demonstrate clinically, histologically genetically distinct. Some recur exhibit aggressive clinical behavior. In such cases, certain histological factors could account for However, features predict adverse outcome poorly defined. current classification CNS tumors, there no option high-grade PXA, even if tumor had numerous recurrences poor outcome. this review, we focus on behavior anaplasia in discuss how our experience suggests modifi...