The use of ciclosporin in psoriasis.

摘要: Ciclosporin is a cyclic undecapeptide discovered in the 1970s to possess potent inhibitory action on T lymphocytes. The subsequent discovery, 1979, that it was remarkably effective treatment of psoriasis transformed thinking about nature disease, which subsequently became generally recognized as autoimmune nature. remains one most and rapidly acting treatments currently available for psoriasis. Virtually all diverse manifestations this disease can respond. main side effects are nephrotoxicity hypertension. There considerable variation between individuals susceptibility these so careful monitoring required. should be used single or intermittent short courses except severe cases safer than continuous treatment. rate improvement depends very much dose, ranges from 2 5.0 mg/kg/day. combined with any topical useful dose-sparing effect achieved way if patients compliant. In ciclosporin often combination other systemic antipsoriatic drugs order spare dose each agent reduce toxicity. Concurrent intercurrent use ultraviolet therapy discouraged due increased risk non-melanoma skin cancer. This article reviews mode action, pharmacokinetics, indications, contraindications, effects, dosage regimens, pretreatment screening monitoring, drug interactions, combinations management