The structural biology of oestrogen metabolism
作者： Mark P. Thomas , Barry V.L. Potter
DOI: 10.1016/J.JSBMB.2012.12.014
关键词:
摘要: Many enzymes catalyse reactions that have an oestrogen as a substrate and/or product. The catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. these must all recognise bind but, despite this, they diverse structures. This review looks at each of in turn, describing the structure discussing mechanism reaction. Since has role many disease states inhibition metabolism may impact on state or progression inhibitors are briefly discussed. article is part Special Issue entitled 'CSR 2013'.
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