Different mechanisms in the tumorigenesis of proximal and distal colon cancers
作者： Annika Lindblom
DOI: 10.1097/00001622-200101000-00013
关键词:
摘要: Environment or genetic constitutions can lead to an increase of epigenetic events and the risk for malignancy. Genomic instability is seen in most types malignancies. Two forms have been described colorectal cancer: chromosomal (CIN),
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sci-hub.se 参考文章(83)
Stephen J. Lanspa, Henry T. Lynch, Thomas C. Smyrk, Patricia Strayhorn, Patrice Watson, Jane F. Lynch, Joseph X. Jenkins, Henry D. Appelman, Colorectal adenomas in the Lynch syndromes. Results of a colonoscopy screening program. Gastroenterology. ,vol. 98, pp. 1117- 1122 ,(1990) , 10.1016/0016-5085(90)90323-S
Jarle Breivik, Gustav Gaudernack, Carcinogenesis and Natural Selection: A New Perspective to the Genetics and Epigenetics of Colorectal Cancer Advances in Cancer Research. ,vol. 76, pp. 187- 212 ,(1999) , 10.1016/S0065-230X(08)60777-0
Hannah L Klein, A radical solution to death. Nature Genetics. ,vol. 25, pp. 132- 134 ,(2000) , 10.1038/75957
Hanan Lamlum, Mohammad Ilyas, Andrew Rowan, Susan Clark, Victoria Johnson, Jennie Bell, Ian Frayling, Jason Efstathiou, Kevin Pack, Stewart Payne, Rebecca Roylance, Patricia Gorman, Denise Sheer, Kay Neale, Robin Phillips, Ian Talbot, Walter Bodmer, Ian Tomlinson, The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nature Medicine. ,vol. 5, pp. 1071- 1075 ,(1999) , 10.1038/12511
Hoguen Kim, Jin Jen, Bert Vogelstein, Stanley R Hamilton, None, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences American Journal of Pathology. ,vol. 145, pp. 148- 156 ,(1994)
Ian Tomlinson, Walter Bodmer, Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog Nature Medicine. ,vol. 5, pp. 11- 12 ,(1999) , 10.1038/4687
Ina Rhee, Kam-Wing Jair, Ray-Whay Chiu Yen, Christoph Lengauer, James G. Herman, Kenneth W. Kinzler, Bert Vogelstein, Stephen B. Baylin, Kornel E. Schuebel, CpG methylation is maintained in human cancer cells lacking DNMT1 Nature. ,vol. 404, pp. 1003- 1007 ,(2000) , 10.1038/35010000
Barry Iacopetta, Jacqueline Gayet, Xiao-Ping Zhou, Gilles Thomas, Richard Hamelin, Alex Duval, Frequent Frameshift Mutations of the TCF-4 Gene in Colorectal Cancers with Microsatellite Instability Cancer Research. ,vol. 59, pp. 4213- 4215 ,(1999)
Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Genetic instabilities in human cancers Nature. ,vol. 396, pp. 643- 649 ,(1998) , 10.1038/25292
Lisa N. Spirio, Wade Samowitz, Jennifer Robertson, Margaret Robertson, Randall W. Burt, Mark Leppert, Ray White., Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nature Genetics. ,vol. 20, pp. 385- 388 ,(1998) , 10.1038/3865