1 Rhodium- and Palladium-Catalyzed Asymmetric Conjugate Additions

摘要: Since the seminal report by Uemura [1] in 1995 for palladium, and Miyaura 1997 rhodium [2], late transition metal-catalyzed conjugate addition of organoboron reagents to activated alkenes has emerged as one most functional group-tolerant reliable carbon–carbon bond-forming processes. The maturity this methodology is such that it become an ideal testing ground new ligand concepts design, will be illustrated throughout chapter. A true statement robustness process application Rh-catalyzed enantioselective (ECA) on a kilogram-scale manufacture advanced pharmaceutical ingredients, its use key step synthesis complex natural products [3–5]. In chapter, overview provided – spanning from 2003 mid-2009 developments field rhodiumand palladium-catalyzed ECA organometallic (B, Si, Zn, Ti) alkenes. chapter not intended comprehensive, include only selected examples powerful methodology. For more in-depth comprehensive accounts, reader should consult number excellent reviews are available subject [6–16].