Heparin-Induced Thrombocytopenia

摘要: Two patients with underlying thromboembolic disorders developed severe thrombocytopenia while receiving heparin sodium; one of these recurrence the and possible heparin-induced pulmonary emboli when was restarted. In a prospective study in coronary care unit (CCU), nine 37 transient mild (platelet counts ranging from 88,000 to 150,000/cu mm). Heparin added citrated platelet-rich plasma caused platelet aggregation two original patients, three six CCU tested, 17 87 other subjects, maximum at concentrations likely be present vivo during therapy. We herein discuss evidence that suggests may cause or aggravate thrombosis by causing aggregation. The occurrence is well documented, more common than has been recognized. Studies efficacy should take responses into account. (Arch Intern Med138:548-552, 1978)