Current Understanding of Group A Streptococcal Biofilms.

摘要: Background It has been proposed that GAS may form biofilms. Biofilms are microbial communities aggregate on a surface, and exist within self-produced matrix of extracellular polymeric substances. offer bacteria an increased survival advantage, in which persist, resist host immunity antimicrobial treatment. The biofilm phenotype long recognized as virulence mechanism for many Gram-positive Gram-negative bacteria, however very little is known about the role biofilms pathogenesis. Objective This review provides overview current knowledge assesses evidence formation, factors modelling biofilms, discusses polymicrobial nature oropharynx relation to GAS. Conclusion Further study needed improve understanding both monospecies biofilm, member biofilm. Improved formation settings closely mimicking vivo conditions will ensure generated lab reflect those occurring during clinical infection.