Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy.

摘要: Repeated administration of low doses puromycin aminonucleoside (PAMN) to rats induces a proteinuric renal disease that resembles focal segmental glomerulosclerosis (FSGS). Reactive oxygen molecules may be involved in the progressive course this nephropathy. Therefore we evaluated whether taurine, an endogenous antioxidant, could limit extent injury. Sprague-Dawley received low-dose injections PAMN, 2 mg/100 g body wt, over 12-wk period. Two groups were studied: 1) controls given tap water (n = 23), and 2) experimental group drank 1% taurine-supplemented 22). Taurine-treated nephrotic had reduction albuminuria, as assessed by urinary albumin-to-creatinine ratio (26 +/- 4 vs. 44 4, P less than 0.0001). After 12 wk, creatinine clearance was 0.33 0.03 (experimental) 0.17 ml.min-1.100 wt-1 (control) (P 0.001), inulin 6 pairs) 0.26 0.04 0.13 0.02 0.025). Administration taurine reduced percentage segmentally sclerosed glomeruli (9.8 1.7 16.2 1.8%, 0.02) tubulointerstitial injury score (1.36 0.19 2.61 0.25, 0.0025) control rats. Taurine treatment normalized elevated cortical malondialdehyde level with PAMN nephropathy 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)