作者: Nathalie Andrieu-Abadie , Thierry Levade
DOI: 10.1016/S1388-1981(02)00332-3
关键词:
摘要: Sphingolipid breakdown products are now being recognized as important players in apoptosis. Ceramide, which is considered to serve second messenger, mainly generated by hydrolysis of the membrane sphingophospholipid sphingomyelin (SM) through action a sphingomyelinase (SMase). However, little known about localization and regulation this phenomenon. Here, we summarize current knowledge on function SM apoptosis signaling. In particular, present review focuses role neutral (N-SMase) generation proapoptotic ceramide. This enzyme regulated several mechanisms, including tumor necrosis factor (TNF) receptor-associated protein FAN (for associated with N-SMase activation) oxidative stress. These observations place SMase activation early events signaling cascade.