Effects of Epiphyseal Proteins and Melatonin on Blood Biochemical Parameters of Fluoride-Intoxicated Rats

摘要: We examined the effects of fluoride intoxication on certain blood plasma biochemical indices in rats. Fortyeight adult female Wistar rats weighing 123-142 g were divided into eight groups: two control groups (0 and 28 days) six experimental groups, namely sham-injected animals (vehicle), injected with pineal proteins (PP) melatonin (Mel), intoxicated (F), also F+PP F+Mel groups. Fluoride (150 ppm, per os administration drinking water), (10 mg/kg, i.p.), PP (100 μg/kg, i.p.) administered daily for days. Blood samples collected at end experiments to estimate [Na+] [K+], alkaline phosphatase (ALP) activity, levels glucose different animal The [K+] [Na+], ALP activity significantly (P < 0.05) elevated F-treated animals, as compared others. Administration Mel caused significant reduction levels. Interestingly, administrations resulted noticeable increases level F-intoxicated other These findings convincingly indicate that exert ameliorative fluoride-induced adverse changes parameters