Survival Benefit for Pediatric Patients With Recurrent Ependymoma Treated With Reirradiation

摘要: Purpose The outcome of recurrent ependymoma in children is dismal. Reirradiation has been proposed as an effective modality for at relapse. However, the toxicity and benefits this approach have not well established. Methods Materials We conducted a retrospective population-based study all patients with treated between 1986 2010 our institution. Demographic, treatment, data were analyzed entire cohort. Results Of 113 intracranial ependymoma, 47 relapsed. At time relapse, 29 surgical resection and/or chemotherapy, 18 received full-dose (≥54 Gy focal craniospinal) reirradiation or without surgery recurrence. was tolerated no severe acute complications noticed. Three-year overall survival 7% ± 6% 81% 12% nonreirradiated reirradiated patients, respectively ( p n = 15; 0.002). mean follow-up 3.73 years, only 2/18 had endocrine dysfunction, 1 patient required special education support. decline intellectual function from pre- to postreirradiation assessment observed. Conclusions treatment that may change natural history children. be associated increased neurocognitive toxicity. Additional needed determine risk late recurrence, secondary radiation-induced tumors, long-term functional these patients.