Immune Gene and Cell Enrichment Is Associated with a Good Prognosis in Ependymoma

摘要: Approximately 50% of children with ependymoma will suffer from tumor recurrences that ultimately lead to death. Development more effective therapies and patient stratification in mandates better prognostication. In this study, gene expression microarray profiles pediatric clinical samples were subject ontological analyses identify outcome-associated biological factors. Histology was subsequently used evaluate the results analyses. Ontology revealed genes associated nonrecurrent predominantly immune function-related. Additionally, increased immune-related correlated longer time progression recurrent ependymoma. Of those both phenotype positively progression, 95% function. Histological analysis a subset these function their restricted subpopulation tumor-infiltrating cells. Analysis cells showed infiltration CD4 + T ependymomas. No genomic sequences for SV40, BK, JC, or Merkel polyomaviruses found This study reveals up-regulation is predominant ontology good prognosis it provides preliminary evidence beneficial host proinflammatory and/or Ag-specific response.