Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease

摘要: Dynamic modulations of large-scale network activity and synchronization are inherent to a broad spectrum cognitive processes disturbed in neuropsychiatric conditions including Parkinson's disease. Here, we set out address the motor disease its modulation with subthalamic stimulation. To this end, 20 patients idiopathic nucleus stimulation were analysed on externally cued right hand finger movements 1.5-s interstimulus interval. Simultaneous recordings obtained from electromyography antagonistic muscles (right flexor digitorum extensor digitorum) together 64-channel electroencephalography. Time-frequency event-related spectral perturbations assessed determine cortical muscular activity. Next, cross-spectra time-frequency domain explore cortico-cortical synchronization. The enabled us select range relevant for processing. On these windows, developed an extension phase index quantify global obtain topographic differentiations distinct electrode sites respect their contributions index. measures used predict clinical reaction time outcome using regression analysis. We found that movement-related desynchronization upper alpha beta was significantly facilitated 'stimulation on' compared off' electrodes over bilateral parietal, sensorimotor, premotor, supplementary-motor, prefrontal areas, inferior areas. These both improvement With on', interhemispheric coherence band attenuated sensorimotor Similarly, attenuated, differentiation revealed stronger (ipsilateral) right-hemispheric prefrontal, premotor areas off'. further demonstrated largely dominated by genuine neuronal coupling. could be predicted decoupling multiple regressions, reduction area showed linear univariate correlation improvement. Our study demonstrates wide-spread network, highlights as network-modulating therapy. Accordingly, may release computational resources facilitating desynchronization. Moreover, is critical balance inhibitory facilitatory players within program.