Cellular mechanisms underlying oxidative stress in human exercise.

摘要: A relative increase in oxidation of lipids, proteins and DNA has been recognised to occur the circulation tissues exercising humans animals since late 1970s throughout ensuing 40 years a great deal work undertaken elucidate potential source(s) this exercise-induced "oxidative stress". Specific aspects physical exercise (e.g. contractile activity, hypoxia, hyperaemia) may theoretically induce increased generation reactive oxygen species number tissues, but data strongly indicate that activity skeletal muscle predominates as source oxidants contributes local extracellular biomaterials. Taken together with relatively large mass compared other cells it appears fibres are major contributor whole body stress" during some forms exercise. The sub-cellular sources have also subject considerable research early studies predominantly indicating mitochondria were likely oxidants, such hydrogen peroxide, assessments concentrations peroxide at rest do not support possibility. In contrast, several recent identified NADPH oxidase enzymes appear play signalling role physiological responses xanthine contribute oxidation. fuller understanding roles these function(s) generated increasingly important attempts harness beneficial effects for maintenance health aging variety chronic conditions.