Prospects for the Treatment of B Cell Tumors Using Idiotypic Vaccination

摘要: Manipulation of the immune system in order specifically to attack autologous tumor cells has been a distant goal, largely due poor definition tumor-associated antigens. By focussing on B cell lymphomas which express molecularly defined clonal marker, idiotypic immunoglobulin, it possible generate anti-idiotypic responses suppress individual tumors. Studies components these are providing insight into host effector mechanisms can be activated against tumors, and also many strategies adopted by target avoid such attack. Promising results various animal models where bearers treated immunization have led point application this approach treatment certain categories human lymphoma considered.