Surface engineering of quantum dots for in vivo imaging.
作者： Chang-Moon Lee , DooRye Jang , Su-Jin Cheong , Eun-Mi Kim , Min-Hee Jeong
DOI: 10.1088/0957-4484/21/28/285102
关键词:
摘要: The aim of this study was to investigate the effect gluconic acid (GA) conjugation on biodistribution cysteamine-capped quantum dots (amino-QDots) in vivo. Cadmium selenide/zinc sulfide (CdSe/ZnS) capped with cysteamine through a thiol exchange method, and different amounts GA were conjugated amine groups via formation an amide bond. emission maxima synthesized QDots, amino-QDots GA-conjugated amine-QDots (GA-QDots) located at 720, 600 610 nm, respectively. In cell viability studies, GA-QDots showed very low toxicity against CHO cells as compared cytotoxicity amino-QDots. QDots next intravenously injected into normal mice then we performed ex vivo optical imaging. majority accumulated lung. contrast, cleared out body kidney. Therefore, expect that onto can create opportunities for using
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