ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension
作者： Justin N. Weilnau , Sarah E. Black , Veronica J. Chehata , Michael P. Schmidt , Kimberly L. Holt
DOI: 10.1002/JAT.2811
关键词:
摘要: As a result of their characteristic physical and optical properties, including size, intense fluorescence, broad excitation, narrow emission resistance to photobleaching, semiconductor nanocrystals are potentially useful for variety biological applications molecular imaging, live-cell labeling, photodynamic therapy targeted drug delivery. In this study, zinc sulfide (ZnS) were synthesized in the 3 4 nm size range with selected capping agents intended protect nanocrystal core increase its compatibility. We show that biocompatibility ZnS primary murine splenocytes is influenced by chemical structure outer agent on nanocrystal. Additionally, cytotoxicity increases markedly as function time spent suspension phosphate-buffered saline (PBS). These data suggest potential therapeutic and/or use inherently dependent upon proper choice agent, well conditions preparation storage. Copyright © 2012 John Wiley & Sons, Ltd.
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