Fat and Beyond: The Diverse Biology of PPARγ
作者： Peter Tontonoz , Bruce M. Spiegelman
DOI: 10.1146/ANNUREV.BIOCHEM.77.061307.091829
关键词:
摘要: The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to variety physiological processes. was initially characterized as master regulator for development adipose cells. Ligands include naturally occurring fatty acids and thiazolidinedione (TZD) class antidiabetic drugs. Activation improves insulin sensitivity rodents humans through combination metabolic actions, including partitioning lipid stores regulation inflammatory mediators termed adipokines. signaling has also been implicated cell proliferation, atherosclerosis, macrophage function, immunity. Here, we review recent advances our understanding diverse biological actions with eye toward expanding therapeutic potential agonist
sci-hub.se 参考文章(170)
Nikolaus Marx, Galina Sukhova, Curran Murphy, Peter Libby, Jorge Plutzky, Macrophages in Human Atheroma Contain PPARγ: Differentiation-Dependent Peroxisomal Proliferator-Activated Receptor γ (PPARγ) Expression and Reduction of MMP-9 Activity through PPARγ Activation in Mononuclear Phagocytes in Vitro American Journal of Pathology. ,vol. 153, pp. 17- 23 ,(1998) , 10.1016/S0002-9440(10)65540-X
T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine. ,vol. 7, pp. 941- 946 ,(2001) , 10.1038/90984
Ken Kishida, Iichiro Shimomura, Hitoshi Nishizawa, Norikazu Maeda, Hiroshi Kuriyama, Hidehiko Kondo, Morihiro Matsuda, Hiroyuki Nagaretani, Noriyuki Ouchi, Kikuko Hotta, Shinji Kihara, Takashi Kadowaki, Tohru Funahashi, Yuji Matsuzawa, Enhancement of the Aquaporin Adipose Gene Expression by a Peroxisome Proliferator-activated Receptor γ Journal of Biological Chemistry. ,vol. 276, pp. 48572- 48579 ,(2001) , 10.1074/JBC.M108213200
Mercedes Ricote, Andrew C. Li, Timothy M. Willson, Carolyn J. Kelly, Christopher K. Glass, The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature. ,vol. 391, pp. 79- 82 ,(1998) , 10.1038/34178
Christopher K. Glass, Joseph L. Witztum, Atherosclerosis: The Road Ahead Cell. ,vol. 104, pp. 503- 516 ,(2001) , 10.1016/S0092-8674(01)00238-0
Todd G Kroll, Pasha Sarraf, Lorenza Pecciarini, Chang-Jie Chen, Elisabetta Mueller, Bruce M Spiegelman, Jonathan A Fletcher, PAX8-PPARγ1 Fusion in Oncogene Human Thyroid Carcinoma Science. ,vol. 289, pp. 1357- 1360 ,(2000) , 10.1126/SCIENCE.289.5483.1357
K. Schoonjans, J. Peinado-Onsurbe, A. M. Lefebvre, R. A. Heyman, M. Briggs, S. Deeb, B. Staels, J. Auwerx, PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene The EMBO Journal. ,vol. 15, pp. 5336- 5348 ,(1996) , 10.1002/J.1460-2075.1996.TB00918.X
Dalei Shao, Shamina M. Rangwala, Shannon T. Bailey, Samuel L. Krakow, Mauricio J. Reginato, Mitchell A. Lazar, Interdomain communication regulating ligand binding by PPAR-γ Nature. ,vol. 396, pp. 377- 380 ,(1998) , 10.1038/24634
Claire M. Steppan, Shannon T. Bailey, Savitha Bhat, Elizabeth J. Brown, Ronadip R. Banerjee, Christopher M. Wright, Hiralben R. Patel, Rexford S. Ahima, Mitchell A. Lazar, The hormone resistin links obesity to diabetes Nature. ,vol. 409, pp. 307- 312 ,(2001) , 10.1038/35053000
K. Teoman Uysal, Sarah M. Wiesbrock, Michael W. Marino, Gkhan S. Hotamisligil, Protection from obesity-induced insulin resistance in mice lacking TNF-|[alpha]| function Nature. ,vol. 389, pp. 610- 614 ,(1997) , 10.1038/39335