The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier
作者： Victor A. Levin , Herbert D. Landahl , Mary A. Freeman-Dove
DOI: 10.1007/BF01064555
关键词:
摘要: Capillary permeability was analyzed in both normal rat brain and intracerebral 9L gliosarcoma tumor rhesus monkey using a newly derived formula for the capillary coefficient (P).The Pvalue isotopic urea sodium less than brain. The 1 log unit higher all but most rapidly transported drugs. Amphotericin B increased galactitol not urea. Glucocorticoids did alter Pvalues sucrose or Using P,drugs can be categorized terms of blood-brain barrier (BBB) exclusion, slow BBB passage, moderate rapid passage. technique described this article is applicable to study regional differences associated with disease states.
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