Estrogen replacement therapy reverses changes in intramural coronary resistance arteries caused by female sex hormone depletion
作者： Metin Mericli , György L Nádasy , Maria Szekeres , Szabolcs Várbíró , Zoltan Vajo
DOI: 10.1016/J.CARDIORES.2003.11.022
关键词:
摘要: Objective: We tested the hypothesis that female sex hormone depletion and estradiol replacement therapy significantly influences biomechanical properties of intramural coronary resistance arteries. Design: Female rats (n=30) were divided into three groups. In group O, subjected to bilateral ovariectomy. Group HRT was ovariectomy therapy. Rats in C served as controls. One month after ovariectomy, arteries (approximately 200 Am diameter) branching from left anterior descending isolated, cannulated studied by microarteriography. Intraluminal pressure increased steps between 0 90 mm Hg. The steady state diameter at each step measured. These measurements repeated presence U46619, a thromboxane (TX) A2 receptor agonist (at concentration 10 6 M), bradykinin (BK; M). Finally, Ca 2+ -free Krebs-induced passive (PD) measured group. Results: Ovariectomy spontaneous myogenic tone (p<0.05), which normalized estrogen replacement. decreased distensibility observed low pressure, although not changed. Estrogen wall stress elastic modulus (p<0.05). induced largest contraction ovariectomized group, whereas bradykinin-induced relaxation Conclusion: Estradiol (HRT) may exert beneficial effect on myocardial perfusion menopause opposing deterioration vessels depletion.
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