Estrogen modulation of left ventricular remodeling in the aged heart.
作者： Yi Xu , Ivan A Arenas , Stephen J Armstrong , Sandra T Davidge
DOI: 10.1016/S0008-6363(02)00705-8
关键词:
摘要: Objective: To investigate the effects of estrogen on left ventricle (LV) mass and collagen deposition, expression receptors for (ERα, ERβ) Ang II (AT2R, AT1R) in heart aged female rats. Methods: Aged (∼12 months old) intact ( n =7), ovariectomized plus placebo (OVX, estrogen-replaced (E2, =6) as well young (∼3 old, =4) Sprague–Dawley rats were used this study. After 1 month treatment, ventricular weight/body weight ratio (LVW/BW), changes myosin heavy chain (MHC), matrix metalloproteinase (MMP)-2 activity, I/III ratio, ERs LV evaluated. Results: In rats, OVX increased LVW/BW associated with a higher β-MHC isoform, decreased MMP-2 activity compared to Furthermore, group had decrease α β AT2R but an increase AT1R expression. Estrogen replacement prevented ovariectomy remodeling further ERβ Conclusion: Removal ovarian hormones rat, which could be attenuated by replacement. Moreover, regulation receptor mechanism may modulate remodeling.
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Raghvendra K. Dubey, Edwin K. Jackson, Invited Review: Cardiovascular protective effects of 17β-estradiol metabolites Journal of Applied Physiology. ,vol. 91, pp. 1868- 1883 ,(2001) , 10.1152/JAPPL.2001.91.4.1868
Ardaillou R, Angiotensin II receptors Journal of The American Society of Nephrology. ,vol. 10, pp. 30- 39 ,(1999)
BERNARD SWYNGHEDAUW, Molecular Mechanisms of Myocardial Remodeling Physiological Reviews. ,vol. 79, pp. 215- 262 ,(1999) , 10.1152/PHYSREV.1999.79.1.215
K. A. Esser, M. O. Boluyt, T. P. White, Separation of cardiac myosin heavy chains by gradient SDS-PAGE American Journal of Physiology-heart and Circulatory Physiology. ,vol. 255, ,(1988) , 10.1152/AJPHEART.1988.255.3.H659
Richard B. Devereux, Mary J. Roman, Giovanni de Simone, Michael J. O’Grady, Mary Paranicas, JeunLiang Yeh, Richard R. Fabsitz, Barbara V. Howard, Relations of Left Ventricular Mass to Demographic and Hemodynamic Variables in American Indians The Strong Heart Study Circulation. ,vol. 96, pp. 1416- 1423 ,(1997) , 10.1161/01.CIR.96.5.1416
Amos Pines, Enrique Z. Fisman, Yoram Levo, Yaacov Drory, Efraim Ben-Ari, Michael Motro, Daniel Ayalon, Menopause-induced changes in left ventricular wall thickness. American Journal of Cardiology. ,vol. 72, pp. 240- 241 ,(1993) , 10.1016/0002-9149(93)90171-8
I. MEDUGORAC, R. JACOB, Characterisation of left ventricular collagen in the rat Cardiovascular Research. ,vol. 17, pp. 15- 21 ,(1983) , 10.1093/CVR/17.1.15
C Heymes, B Swynghedauw, B Chevalier, Activation of angiotensinogen and angiotensin-converting enzyme gene expression in the left ventricle of senescent rats. Circulation. ,vol. 90, pp. 1328- 1333 ,(1994) , 10.1161/01.CIR.90.3.1328
Maria Grazia Modena, Nicola Muia, Pietro Aveta, Rosella Molinari, Rosario Rossi, Effects of Transdermal 17β-Estradiol on Left Ventricular Anatomy and Performance in Hypertensive Women Hypertension. ,vol. 34, pp. 1041- 1046 ,(1999) , 10.1161/01.HYP.34.5.1041
Andrew L. Dannenberg, Daniel Levy, Robert J. Garrison, Impact of age on echocardiographic left ventricular mass in a healthy population (the Framingham study) American Journal of Cardiology. ,vol. 64, pp. 1066- 1068 ,(1989) , 10.1016/0002-9149(89)90816-3