Multilamellar Structures and Filament Bundles Are Found on the Cell Surface during Bunyavirus Egress

摘要: Inside cells, viruses build specialized compartments for replication and morphogenesis. We observed that virus release associates with specific structures found on the surface of mammalian cells. Cultured adherent cells were infected a bunyavirus processed oriented sectioning transmission electron microscopy. Imaging cell basal regions showed sophisticated multilamellar (MLS) extracellular filament bundles attached viruses. Correlative light microscopy confirmed both MLS filaments proliferated during maximum egress new dimensions structure reminiscent those reported nanostructures gecko fingertips, which are responsible extraordinary attachment capacity these lizards. As more resistant to detachment than control we propose an adhesive function structures, would compensate loss adherence progeny.