Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.

摘要: Medulloblastoma accounts for almost one-third of pediatric central nervous system (CNS) cancers, but is very rare in the adult population. As a result, patients with medulloblastoma are often treated according to therapies developed children similarly staged disease at diagnosis, based on assumption that and tumors have similar properties. The purpose this review was summarize evidence make recommendations management recurrent medulloblastoma. We conducted systematic literature search find publications addressing treatment adults. Current strategies relapsed results retrospective case series published consensus recommendations, include maximal safe re-resection where possible, combined chemotherapy and/or re-irradiation. describe 13 involving 66 high-dose (HDCT) plus stem cell transplantation HDCT may be option small proportion who unlikely benefit from conventional fit their recurrence contained within CNS. Potential cases which being considered should discussed multidisciplinary tumor board includes involvement by hematologic oncologists transplant specialists.