High resolution mass spectrometry-based screening reveals lipophilic toxins in multiple trophic levels from the North Sea.

摘要: Abstract Lipophilic marine biotoxins, which are mainly produced by small dinoflagellates, increasingly detected in coastal waters across the globe. As these producers consumed zooplankton and shellfish, toxins introduced, bioaccumulated possibly biomagnified throughout food chains. Recent research has demonstrated that ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC–HRMS) is an excellent tool detect algae seafood. In this study, UHPLC–HRMS was used screen lipophilic biotoxins organisms from different trophic levels of Belgian zone ecosystem. A total 20 tentatively identified compounds detected. Hereby, transfer upper level considered be rather limited. Furthermore, 36% clearly transferred between organisms. significant biotransformation okadaic acid spirolide toxin groups observed (64%), filter feeders. Through a multi-targeted approach, study showed exposed multi-toxin mixture. Further on both single compound interactive toxic effects frequently ester metabolites chain therefore needed. future perspective, confirmatory identification potential studying their fragmentation spectra (using new tools such as hybrid quadrupole Q-Exactive™ Orbitrap-MS) designated.