An advanced mouse model for human skin wound healing.

作者: Jie Wen , Xiangyong Li , Xue Leng , Xin Xu , Xunwei Wu

DOI: 10.1111/EXD.13258

关键词:

摘要: Here, we report a model for studying wound repair based on skin regenerated from human tissue culture-expanded cells. The reconstituted (hRSK) responds to injury similar that of intact skin, and its constituent cells contribute the healing process. As have demonstrated hRSK composed GFP-labelled also heals "normally," believe this will be useful in analysing process using genetically modified

参考文章(10)
Xunwei Wu, Larry Scott, Ken Washenik, Kurt Stenn, Full-Thickness Skin with Mature Hair Follicles Generated from Tissue Culture Expanded Human Cells Tissue Engineering Part A. ,vol. 20, pp. 3314- 3321 ,(2014) , 10.1089/TEN.TEA.2013.0759
Michel Demarchez, Philippe Sengel, M. Prunieras, Wound healing of human skin transplanted onto the nude mouse Developmental Biology. ,vol. 113, pp. 90- 96 ,(1986) , 10.1016/0012-1606(86)90110-7
Moein Momtazi, Peter Kwan, Jie Ding, Colin C. Anderson, Dariush Honardoust, Serge Goekjian, Edward E. Tredget, A nude mouse model of hypertrophic scar shows morphologic and histologic characteristics of human hypertrophic scar. Wound Repair and Regeneration. ,vol. 21, pp. 77- 87 ,(2013) , 10.1111/J.1524-475X.2012.00856.X
María José Escámez, Marta García, Fernando Larcher, Alvaro Meana, Evangelina Muñoz, Jose Luis Jorcano, Marcela Del Río, An In Vivo Model of Wound Healing in Genetically Modified Skin-Humanized Mice Journal of Investigative Dermatology. ,vol. 123, pp. 1182- 1191 ,(2004) , 10.1111/J.0022-202X.2004.23473.X
David J. Geer, Daniel D. Swartz, Stelios T. Andreadis, In vivo model of wound healing based on transplanted tissue-engineered skin. Tissue Engineering. ,vol. 10, pp. 1006- 1017 ,(2004) , 10.1089/TEN.2004.10.1006
L. Martínez-Santamaría, S. Guerrero-Aspizua, M. Del Río, Bioingeniería cutánea: aplicaciones preclínicas y clínicas Actas Dermo-Sifiliográficas. ,vol. 103, pp. 5- 11 ,(2012) , 10.1016/J.AD.2011.03.006
Mirco Iotti, Marco Leonardi, Enrico Lancellotti, Elena Salerni, Marilena Oddis, Pamela Leonardi, Claudia Perini, Giovanni Pacioni, Alessandra Zambonelli, Spatio-Temporal Dynamic of Tuber magnatum Mycelium in Natural Truffle Grounds PLoS ONE. ,vol. 9, pp. e115921- 18 ,(2014) , 10.1371/JOURNAL.PONE.0115921
Nkemcho Ojeh, Irena Pastar, Marjana Tomic-Canic, Olivera Stojadinovic, Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications International Journal of Molecular Sciences. ,vol. 16, pp. 25476- 25501 ,(2015) , 10.3390/IJMS161025476
S. A. Eming, P. Martin, M. Tomic-Canic, Wound repair and regeneration: Mechanisms, signaling, and translation Science Translational Medicine. ,vol. 6, ,(2014) , 10.1126/SCITRANSLMED.3009337
S. E. Soden, C. J. Saunders, L. K. Willig, E. G. Farrow, L. D. Smith, J. E. Petrikin, J.-B. LePichon, N. A. Miller, I. Thiffault, D. L. Dinwiddie, G. Twist, A. Noll, B. A. Heese, L. Zellmer, A. M. Atherton, A. T. Abdelmoity, N. Safina, S. S. Nyp, B. Zuccarelli, I. A. Larson, A. Modrcin, S. Herd, M. Creed, Z. Ye, X. Yuan, R. A. Brodsky, S. F. Kingsmore, Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders Science Translational Medicine. ,vol. 6, pp. 265- ,(2014) , 10.1126/SCITRANSLMED.3010076