Extracellular matrix and inner ear development and function

摘要: Publisher Summary The structures of the inner ear are replete with both structural Extracellular matrix (ECM) as well intricate networks basement membranes. This chapter focuses upon cochlear portion ear. is comprised two systems: cochlea, which provides information relating to hearing, and vestibular system, sensory critical balance. As cochlea functions translate physical sound waves into sensori-neural input, structure ECM centrally important architecture. evolves matures appropriate characteristics assist in amplification neural energy. Defects this delicate balance evident mutant mice for tectorin α β subunits changes tectorial membrane result reduced efficiency or ablation amplifier function outer hair cells. role membranes less clear. dynamic transitions composition during development suggest may direct differentiation and/or terminal cytodifferentiation complex cellular compartments epithelium.