Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases

摘要: Abstract Several degenerative diseases of the nervous system are characterized by presence neuronal inclusions. Most these inclusions made abnormal filaments and share epitopes with cytoskeletal proteins. One inclusions, neurofibrillary tangle Alzheimer disease, has recently been shown to contain ubiquitin, a regulatory protein thought play role in degradation We carried out light electron microscopic immunocytochemistry several polyclonal monoclonal antibodies investigate ubiquitin neurodegenerative diseases. Ubiquitin was present not only paired helical that form but also filamentous components inclusion characteristic Parkinson Pick progressive supranuclear palsy. In contrast, detected other often found aging such as Hirano bodies granulovacuolar degeneration. Reactivity suggests differences ubiquitin-acceptor proteins studied. It is concluded selectively