Oxidative stress in β-thalassaemia and sickle cell disease

摘要: Sickle cell disease and β-thalassaemia are inherited haemoglobinopathies resulting in structural quantitative changes the β-globin chain. These lead to instability of generated haemoglobin or globin chain imbalance, which turn impact oxidative environment both intracellularly extracellularly. The ensuing stress inability body adequately overcome it are, a large extent, responsible for pathophysiology these diseases. This article provides an overview main players control mechanisms involved establishment haemoglobinopathies.