Modulation of Pseudomonas aeruginosa Quorum Sensing by Glutathione.

摘要: ABSTRACT Pseudomonas aeruginosa uses quorum sensing (QS) to regulate the production of a battery secreted products. At least some these products are shared among population and serve as public goods. When P. is grown on casein sole carbon energy source, QS-induced extracellular protease elastase required for growth. We isolated variant, which showed increased factors after repeated transfers in broth. This QS*, had mutation glutathione synthesis gene gshA . describe several experiments that show coding variant affect QS response. The transcription factor LasR has redox-sensitive cysteine (C79). report GshA cells with C79S substitution similar response wild-type aeruginosa. Surprisingly, it not but RhlR more active bacteria containing Our results demonstrate integrates information about cell density cellular redox state via levels. IMPORTANCE other coordinate group behaviors using chemical communication system called (QS). complex, regulators signals. decreased levels lead activation aeruginosa, did occur strain carrying redox-insensitive factor. ability integrate shows can fine-tune they control at two types signals or cues.