Human umbilical cord blood-derived stromal cells prevent graft-versus-host disease in mice following haplo-identical stem cell transplantation
作者： Lei Hao , Lei Gao , Xing-Hua Chen , Zhong-Min Zou , Xi Zhang
DOI: 10.3109/14653249.2010.501786
关键词:
摘要: AbstractBackground aims. Human umbilical cord blood-derived stromal cells (hUCBDSC) comprise a novel population of CD34+ that has been isolated in our laboratory. They have shown previously not only to be non-immunogenic but also exert immunosuppressive effects on xenogenic T vitro. This study investigated the role hUCBDSC immunomodulation an acute graft-versus-host disease (GvHD) mouse model after haplo-identical stem cell transplantation. Methods. Acute GvHD was induced recipient (B6 × BALB/c)F1 mice by irradiation (750 cGy) followed infusion bone marrow and splenocytes from donor C57BL/6 mice. were co-transplanted experimental group. The survival time, body weight clinical histopathologic scores recorded expression surface markers [major histocompatibility complex (MHC) I, MHC II, CD80 CD86] CD11c+ dendritic (DC), percentage CD4+ regulatory (Treg), spleens r...
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