Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.

作者: Yoshiko Chuman , Ann-Charlotte Bergman , Takayuki Ueno , Shin'ichi Saito , Kazuyasu Sakaguchi

DOI: 10.1016/S0014-5793(99)01493-3

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摘要: A pair of 35 kDa polypeptides (TAO1/TAO2) are expressed in more than 90% all primary lung adenocarcinomas but not other major malignancies. Mass spectrometry tryptic peptides showed that TAO1/TAO2 is identical to napsin A, a recently described member the aspartic proteinase family. The site processing pronapsin mature form was located. Napsin expression detected human adenocarcinoma tumors, compatible with marker nature diagnosis adenocarcinoma. This important since identification markers which can distinguish from distant metastases desirable. Northern blot analysis also normal and kidney tissue, situ hybridization type II alveolar cells lung. protease concluded have specific functional role epithelium candidate for proteolytic surfactant precursors.

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