bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.

摘要: The role of bcl-2 expression in solid tumours is as yet undefined. It was, therefore, the purpose this study to investigate protein 111 human breast carcinomas using immunohistochemistry and monoclonal antibody 124. Expression was then compared with established indicators prognosis biological behaviour malignant disease. No relationship could be observed between node status, tumour size, differentiation, type or age at excision. However, a strong positive seen oestrogen receptor (ER), 70 88 (80%) bcl-2-positive being ER also, seven 23 (30%) bcl-2-negative (P < 0.0001). converse found when epidermal growth factor (EGFR). A negative observed, 26 EGFR positive, 16 (70%) = 0.001), raising possibility that an ER-regulated gene. An inverse also oncogenes c-erbB-2 p53. Thus, loss cancer associated range molecular markers poor may define part ER-negative, EGFR-positive phenotype.