Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea

摘要: Summary Purpose:  The relationship of postictal generalized electroencephalography (EEG) suppression (PGES) with sudden unexpected death in epilepsy (SUDEP) is controversial. It has been suggested that PGES associated respiratory inhibition leading to SUDEP, but the between and depression unknown. Respiratory rate amplitude airflow increase following seizures there persistent hypercapnia hypoxemia. To determine whether result dysfunction, we analyzed parameters recorded during video-EEG telemetry patients localization-related epilepsy. Methods:  Secondarily convulsive (GC) on scalp EEG or bilateral attenuation (BA) intracranial recordings were compared GC without PGES/BA. Oxygen desaturation nadir duration, end-tidal CO2 (ETCO2), apnea duration seizure component PGES/BA. Key Findings:  There was no significant difference (n = 30) PGES/BA (n = 72) for total convulsion. had a mean oxygen 68.8 ± 11.8% (71.5, 43–88) (mean ± standard deviation [median, range]) lower (p = 0.002) than (76.31 ± 10.17% [79, 42–93]). significantly longer peak ETCO2 higher duration. Apnea did not start typically extend into period PGES/BA. Significance:  central more likely related severity seizure-associated intrinsic pulmonary dysfunction.