Effects of dimethyl sulfoxide on lipid membrane electroporation.

摘要: Pores can be generated in lipid membranes by the application of an external electric field or addition particular chemicals such as dimethyl sulfoxide (DMSO). Molecular dynamics (MD) has been shown to a useful tool for unveiling many aspects pore formation both situations. By means MD simulations, we address electropores cholesterol-containing bilayers under influence DMSO. We show how combination physical and chemical mechanisms leads more favorable conditions generating membrane pores and, particular, DMSO medium significantly reduces minimum required electroporate membrane. The strong alteration transversal properties energetic stabilization hydrophobic stage provide physicochemical that explain this effect.