Xanthophylls, phytosterols and pre-β1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study.

摘要: Fenofibrate and extended-release (ER) niacin similarly raise high-density lipoprotein cholesterol (HDL-C) concentration but their effects on levels of potent plasma antioxidant xanthophylls (lutein zeaxanthin) phytosterols obtained from dietary sources, any relationship with lipoproteins pre-β1-HDL levels, have not been investigated. We studied these parameters in 66 dyslipidemic patients treated for 6 week fenofibrate (160 mg/day) or ER-niacin (0.5 g/day 3 week, then 1 g/day) a cross-over study. Both treatments increased HDL-C (16 %) apolipoprotein (apo) A-I (7 only apoA-II (28 %). Lutein zeaxanthin were unaffected by inversely correlated percentage change apoB low-density positively end treatment apoA-II. ApoA-II isolated HDL vitro bound more lutein than apoA-I. Xanthophylls (each ~30 without correlation to apo levels. Only markedly decreased markers absorption; was significantly (−19 %, p < 0.0001), little (3.4 ER-niacin. Although apoA-I, xanthophylls, differed markedly, suggesting differences intestinal lipidation HDL. In addition, the investigations suggest an important role xanthophyll metabolism.