State of the Science: Apathy As a Model for Investigating Behavioral and Psychological Symptoms in Dementia.

摘要: Apathy is one of the most common and pervasive behavioral psychological symptoms dementia (BPSDs). has profound consequences for morbidity, mortality, caregiver burden. Treatment apathy been hindered because poor understanding mechanisms underlying this heterogeneous syndrome. Research demonstrated that associated with disruption frontal-striatal system in individuals neurodegenerative disease. As other BPSDs, these neural alone do not completely account syndrome; individual, caregiver, environmental factors also contribute to apathy. In article, we modify a current conceptual model contributing BPSDs examine determinants This integrative provides more complete theoretically informed apathy, allowing greater insight into potential targets research, intervention, care. We end by proposing an agenda moving science general, particular, forward.