Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors
作者： M. R. Meyer , D. J. Clegg , E. R. Prossnitz , M. Barton
DOI: 10.1111/J.1748-1716.2010.02237.X
关键词:
摘要: Obesity increases the risk of coronary artery disease through insulin resistance, diabetes, arterial hypertension and dyslipidemia. The prevalence obesity has increased worldwide is particularly high among middle-aged women men. After menopause, are at an to develop visceral due loss endogenous ovarian hormone production. Effects oestrogens classically mediated by two nuclear oestrogen receptors (ERs) α β. In addition, more recent research shown that intracellular transmembrane G-protein-coupled receptor (GPER) originally designated as GPR30 also mediates some actions attributed oestrogens. Oestrogen its important regulators body weight sensitivity not only in but men demonstrated ER mutations rodents humans. This article reviews role sex hormones ERs context obesity, diabetes well related clinical issues
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