Coordinating ERK/MAPK signalling through scaffolds and inhibitors

摘要: The pathway from Ras through Raf and MEK (MAPK ERK kinase) to ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein regulates many fundamental cellular processes. Recently, a number of scaffolding proteins endogenous inhibitors have been identified, their important roles in regulating signalling this are now emerging. Some scaffolds augment the signal flux, but also mediate crosstalk with other pathways; certain adaptors target MEK-ERK/MAPK complexes subcellular localizations; others provide regulated inhibition. Computational modelling indicates that, together, these modulators can determine dynamic biological behaviour pathway.