VEGF, ANGPT1, ANGPT2, and MMP-9 expression in the autologous hematopoietic stem cell transplantation and its impact on the time to engraftment
作者： Mateusz Nowicki , Agnieszka Wierzbowska , Roman Małachowski , Tadeusz Robak , Olga Grzybowska-Izydorczyk
DOI: 10.1007/S00277-017-3133-4
关键词:
摘要: As a site of complicated interactions among cytokines, bone marrow niche has been the subject many scientific studies, mainly in context proteins influencing damage or recovery endothelium after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we aimed at exploring mutual correlations cytokines involved homing and mobilization cells, as well angiogenesis. The aim our study was to evaluate levels cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), matrix metalloproteinase 9 (MMP-9) during autologous HSCT examine their influence on hematological recovery. Forty-three patients with malignancies (33 multiple myeloma, 10 lymphoma) were enrolled study. Plasma samples taken five time points: before conditioning treatment (BC), day (0) 7 (+7), 14 (+14), 21 (+21) days HSCT. cytokine evaluated by ELISA method. Our revealed decreased ANGPT1, MMP-9 early post-transplant period compared baseline (BC). ANGPT2 treatment, but tended increase from +7. On +7, positive between ANGPT1 level engraftment observed. opposite negative correlation +7 noticed. suggests that investigated are an important part environment significantly
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